Personally i was let down by the end fight in NV. There just wasn't much that stood out to me in NV. It seemed like a big ass chore rather then an awesome universe.

But in fairness, i had everyone working with me so i encountered little resistance.

I loved F3 though. My only "complaint" is that they should have made the giant super mutants (I forgot the name, the building tall fuckers) more of a rare randomly occurring event rather then scripted.